|
KMID : 0356619930080010027
|
|
Journal of Korean Society of Endocrinology
1993 Volume.8 No. 1 p.27 ~ p.34
|
|
|
Gonadotropin-Releasing Hormone(GnRH) Therapy in Male Patients with hypothalamic Hypogonadism
|
|
박석원
정윤석/정춘희/김성은/이은직/이현철/허갑범/최형기/이무상
|
|
|
Abstract
|
|
|
ABSTRACT
@EN Hypothalamic hypogonadism characterized by low plasma gonadotropin and gonadal steroid hormone concentrations results in absent or incomplete pubertal development and it appears to be due to a deficiency of gonadotropin-releasing hormone
(GnRH).
Early attempts at reversing GnRH deficiency with continuous administration of GnRH or alternatively, using long-acting GnRH agnosists, were largely unsuccessful in achieving a complete normalization of pituitary and gonadal function. But recently
pulsatile infusion pump was developed and long term pulsatile administration of GnRH can be possible. So we applied long term GnRH therapy using pulsatile infusion pump in six male patients with hypothalamic hypogonadism. Plasma luteinzing
hormone,
follicle-stimulating hormone and testosterone levels were followed-up monthly and Tanner staging, measurement of testicular volume and semen-analysis were performed before and after treatment.
@ES The results were as following:
@EN 1) Plasma luteinzing hormone, follicle-stimulating hormone and testosterone levels were significantly increased after pulsatile administration of GnRH.
2) Testicular volume was significantly increased from 7.33ml to 13.17ml (mean value) after pulsatile administration of GnRH.
3) Tanner stage was significantly increased from 2 to 3.5 (mean value) after pulsatile administration GnRH.
4) After pulsatile administration of GnRH, four among six patients showed the evidence of effective spermatogenesis.
In conclusion, GnRH therapy using pulsatile infusion pump could successfully induce pituitary gonadotropin release, develop secondary sexual characteristics and stimulate effective spermatogenesis. (J Kor Soc Endocrimol 8:27~34, 1993).
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|